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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Apoptosis > UMI-77CAS：518303-20-3
Molecular Formula：C18H14BrNO5S2
Molecular Weight：468.34
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 518303-20-3 |
| Name | UMI-77 |
| Molecular Formula | C18H14BrNO5S2 |
| Molecular Weight | 468.34 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00084778 |
| SMILES | C1=CC=C2C(=C1)C(=CC(=C2O)SCC(=O)O)NS(=O)(=O)C3=CC=C(C=C3)Br |
| InChIKey | WUGANDSUVKXMEC-UHFFFAOYSA-N |
| InChI | InChI=1S/C18H14BrNO5S2/c19-11-5-7-12(8-6-11)27(24,25)20-15-9-16(26-10-17(21)22)18(23)14-4-2-1-3-13(14)15/h1-9,20,23H,10H2,(H,21,22) |
| PubChem CID | 992586 |
| Target Point | MCL-1 |
| Passage | Apoptosis |
| Background | UMI-77 is a selective Mcl-1 inhibitor. |
| Biological Activity | UMI-77是一种选择性的 Mcl-1 抑制剂，对 Mcl-1 具有高亲和力 (IC50= 0.31 μM)。UMI-77 结到 Mcl-1 的 BH3 结合沟， Ki 值为 490 nM，比作用于 Bcl-2 家族其他成员的选择性高。[1] |
| Data Literature Source | [1]. Abulwerdi F，et al. A novel small-molecule inhibitor of mcl-1 blocks pancreatic cancer growth in vitro and in vivo. Mol Cancer Ther. 2014 Mar;13(3):565-575 |
| Unit | Bottle |
| Specification | 5mg 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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