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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > SalubrinalCAS：405060-95-9
Molecular Formula：C21H17Cl3N4OS
Molecular Weight：479.81
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to brown Solid
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| CAS | 405060-95-9 |
| Name | Salubrinal |
| Molecular Formula | C21H17Cl3N4OS |
| Molecular Weight | 479.81 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to brown Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00548612 |
| SMILES | O=C(NC(NC(NC1=CC=CC2=C1N=CC=C2)=S)C(Cl)(Cl)Cl)/C=C/C3=CC=CC=C3 |
| Target Point | eIF2α |
| Passage | Cell Cycle |
| Background | Salubrinal is a selective inhibitor of eIF2α dephosphorylation. |
| Biological Activity | Salubrinal是可渗透细胞，选择性的eIF2α去磷酸化抑制剂。Salubrinal是最近发现的PP1抑制剂。[1-2] |
| Data Literature Source | [1]. Drexler HC. Synergistic Apoptosis Induction in Leukemic Cells by the Phosphatase Inhibitor Salubrinal and Proteasome Inhibitors. PLoS One. 2009;4(1):e4161. [2]. Hamamura K，et al. Salubrinal acts as a Dusp2 inhibitor and suppresses inflammation in anti-collagen antibody-induced arthritis. Cell Signal. 2015 Apr;27(4):828-35. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg 25mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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