Your Position: Home > Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Apoptosis > PAC-1

PAC-1

Manual Download

Cat.No：IP1900 Solarbio

CAS：315183-21-2

Molecular Formula：C₂₃H₂₈N₄O₂

Molecular Weight：392.49

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to yellow Solid

Qty：

Size：

Add to cart

Product Information Experimental Images Related Products Related Paper Technical Q&A

Product Information

CAS	315183-21-2
Name	PAC-1
Molecular Formula	C₂₃H₂₈N₄O₂
Molecular Weight	392.49
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD02051977
SMILES	O=C(N/N=C/C1=CC=CC(CC=C)=C1O)CN2CCN(CC3=CC=CC=C3)CC2
Target Point	Caspase
Passage	Apoptosis
Background	PAC-1 is a procaspase-3 activator.
Biological Activity	PAC-1 是一种 procaspase-3 激活剂，诱导癌细胞凋亡，EC50 为 2.08 μM[1-3]。
IC50	Procaspase-3:2.08μM(EC50)[1-3]
Data Literature Source	[1]. Wang F，et al. A novel small-molecule activator of procaspase-3 induces apoptosis in cancer cells and reduces tumor growth in human breast，liver and gallbladder cancer xenografts. Mol Oncol. 2014 Dec;8(8):1640-52. [2]. Seervi M，et al. ERO1α-dependent endoplasmic reticulum-mitochondrial calcium flux contributes to ER stress and mitochondrial permeabilization by procaspase-activating compound-1 (PAC-1). Cell Death Dis. 2013 Dec 19;4:e968. [3]. Putt KS，et al. Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy. Nat Chem Biol. 2006 Oct;2(10):543-50.
Unit	Bottle
Specification	5mg 10mM*1mL in DMSO 10mg 20mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

Note：

1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.

2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.

3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.