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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Apoptosis > AZD5991CAS：2143010-83-5
Molecular Formula：C35H34ClN5O3S2
Molecular Weight：672.26
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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| CAS | 2143010-83-5 |
| Name | AZD5991 |
| Molecular Formula | C35H34ClN5O3S2 |
| Molecular Weight | 672.26 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | O=C(O)C1=C(CCCOC2=C(C=CC=C3)C3=CC4=C2)C5=C(N1C)C(C6=C(C)N(C)N=C6CSCC7=NN(C)C(CS4)=C7)=C(Cl)C=C5 |
| Target Point | Mcl-1 |
| Passage | Apoptosis |
| Background | AZD5991 is an MCL-1 inhibitor. |
| Biological Activity | AZD5991是MCL-1抑制剂，Ki值为0.13 nM。AZD5991对小鼠源Mcl-1的结合亲和力比对人源Mcl-1低25倍，而之比对大鼠源Mcl-1的亲和力低4倍。[1-3] |
| Data Literature Source | [1] Tron AE，et al. Nat Commun. 2018，9(1):5341. [2] Garner TP，et al. Curr Opin Chem Biol. 2017，39:133-142. [3] Adriana E. Tron，et al. AACR Cancer Res. 2018，78(13 Suppl):Abstract nr 302. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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