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RITA

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Cat.No：IR0660 Solarbio

CAS：213261-59-7

Molecular Formula：C₁₄H₁₂O₃S₂

Molecular Weight：292.37

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Light yellow to yellow Solid

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Product Information

CAS	213261-59-7
Name	RITA
Molecular Formula	C₁₄H₁₂O₃S₂
Molecular Weight	292.37
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Light yellow to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 200-256-5
MDL	MFCD03235294
SMILES	OCC1=CC=C(C2=CC=C(C3=CC=C(CO)S3)O2)S1
Target Point	p53
Passage	Apoptosis
Background	RITA is a potent inhibitor of the p53-HDM-2 interaction.
Biological Activity	RITA 是一种有效的 p53-HDM-2 相互作用抑制剂，可与 p53dN 结合，Kd 值为 1.5 nM，同时能够诱导 DNA-DNA 交联。[1-3]
Data Literature Source	[1]. Issaeva N，et al. Small molecule RITA binds to p53，blocks p53-HDM-2 interaction and activates p53 function in tumors. Nat Med. 2004 Dec;10(12):1321-8. Epub 2004 Nov 21. [2]. Nieves-Neira W，et al. DNA protein cross-links produced by NSC 652287，a novel thiophene derivative active against human renal cancer cells. Mol Pharmacol. 1999 Sep;56(3):478-84. [3]. Zhao CY，et al. Rescue of p53 function by small-molecule RITA in cervical carcinoma by blocking E6-mediated degradation. Cancer Res. 2010 Apr 15;70(8):3372-81.
Unit	Bottle
Specification	5mg 10mg 50mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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