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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Apoptosis > A-1210477CAS：1668553-26-1
Molecular Formula：C46H55N7O7S
Molecular Weight：850.04
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1668553-26-1 |
| Name | A-1210477 |
| Molecular Formula | C46H55N7O7S |
| Molecular Weight | 850.04 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD28399118 |
| SMILES | O=C(C(N1CCN2CCOCC2)=C(CCCOC3=C4C=CC=CC4=CC=C3)C5=C1C(C6=C(COC7=CC=C(N8CCN(S(=O)(N(C)C)=O)CC8)C=C7)N(C)N=C6C)=CC=C5)O |
| Target Point | Mcl-1 |
| Passage | Apoptosis |
| Background | A-1210477 is a potent and selective MCL-1 inhibitor. |
| Biological Activity | A-1210477 is a potent and selective inhibitor of MCL-1 with a Ki of 0.45 nM[1]. A-1210477 specifically binds MCL-1 and promotes apoptosis of cancer cells in an MCL-1-dependent manner[2]. |
| Data Literature Source | [1]. Leverson JD，et al. Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax). Cell Death Dis. 2015 Jan 15;6:e1590. [2]. Qing Wang，et al. A-1210477，a selective MCL-1 inhibitor，overcomes ABT-737 resistance in AML. Oncol Lett. 2019 Nov;18(5):5481-5489. |
| Unit | Bottle |
| Specification | 5mg 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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