Your Position: Home > Small Molecule Compounds > Inhibitors & Antagonists & Agonists > ER Stress > ISRIB (trans-isomer)

ISRIB (trans-isomer)

Manual Download

Cat.No：II0860 Solarbio

CAS：1597403-47-8

Molecular Formula：C₂₂H₂₄Cl₂N₂O₄

Molecular Weight：451.34

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

Qty：

Size：

Add to cart

Product Information Experimental Images Related Products Related Paper Technical Q&A

Product Information

CAS	1597403-47-8
Name	ISRIB (trans-isomer)
Molecular Formula	C₂₂H₂₄Cl₂N₂O₄
Molecular Weight	451.34
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD27952932
SMILES	O=C(N[C@@H]1CC[C@@H](NC(COC2=CC=C(Cl)C=C2)=O)CC1)COC3=CC=C(Cl)C=C3
InChIKey	HJGMCDHQPXTGAV-UHFFFAOYSA-N
InChI	InChI=1S/C22H24Cl2N2O4/c23-15-1-9-19(10-2-15)29-13-21(27)25-17-5-7-18(8-6-17)26-22(28)14-30-20-11-3-16(24)4-12-20/h1-4,9-12,17-18H,5-8,13-14H2,(H,25,27)(H,26,28)
PubChem CID	1011240
Target Point	PERK
Passage	ER Stress;Cell Cycle
Background	ISRIB (trans-isomer) is a potent PERK inhibitor.
Biological Activity	ISRIB (trans-isomer)是高效的PERK抑制剂，IC50值为5 nM。[1-2]
IC50	PERK:5nM [1-2]
Data Literature Source	[1]. Sidrauski C，et al. Pharmacological brake-release of mRNA translation enhances cognitive memory. Elife. 2013 May 28;2:e00498. [2]. Sidrauski C，et al. The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stressgranule assembly. Elife. 2015 Feb 26;4. doi: 10.7554/eLife.05033.
Unit	Bottle
Specification	10mg 25mg 50mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

Note：

1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.

2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.

3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.