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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > CambinolCAS：14513-15-6
Molecular Formula：C21H16N2O2S
Molecular Weight：360.43
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 14513-15-6 |
| Name | Cambinol |
| Molecular Formula | C21H16N2O2S |
| Molecular Weight | 360.43 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD09057543 |
| SMILES | O=C(C(CC1=C2C=CC=CC2=CC=C1O)=C(C3=CC=CC=C3)N4)NC4=S |
| Target Point | Sirtuin |
| Passage | Cell Cycle;DNA Damage/DNA Repair; Epigenetics |
| Background | Cambinol is a novel, noncompetitive nSMase2 inhibitor. |
| Biological Activity | Cambinol is a SIRT1 and SIRT2 inhibitor with IC50 values of 56 μM and 59 μM, respectively. Cambinol is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)[1-2]. |
| Data Literature Source | [1]. Heltweg B，et al. Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Res. 2006 Apr 15;66(8):4368-77. [2]. Huarui Zhang，et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1322-1330. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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