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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Apoptosis > CBL0137 HydrochlorideCAS：1197397-89-9
Molecular Formula：C21H24N2O2·HCl
Molecular Weight：372.89
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Off-white to yellow Solid
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| CAS | 1197397-89-9 |
| Name | CBL0137 Hydrochloride |
| Molecular Formula | C21H24N2O2·HCl |
| Molecular Weight | 372.89 |
| Solubility | Soluble in Water/DMSO |
| Purity | ≥98% |
| Appearance | Off-white to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD28160457 |
| SMILES | CC(NCCN1C2=C(C3=C1C=CC(C(C)=O)=C3)C=C(C(C)=O)C=C2)C.[H]Cl |
| Target Point | p53;NF-kB |
| Passage | Apoptosis;NF-kB |
| Background | CBL0137 Hydrochloride is an inhibitor of histone chaperone FACT and can also activate p53 and inhibit NF-κB. ) |
| Biological Activity | CBL0137 hydrochloride is an inhibitor of the histone chaperone， FACT. CBL0137 hydrochloride can also activate p53 and inhibits NF-κB with EC50s of 0.37 and 0.47 μM， respectively.[1-2] |
| Data Literature Source | [1]. Burkhart C， et al. Curaxin CBL0137 eradicates drug resistant cancer stem cells and potentiates efficacy of gemcitabine in preclinical models of pancreatic cancer. Oncotarget. 2014 Nov 30;5(22):11038-53. [2]. Gasparian AV， et al. Curaxins: anticancer compounds that simultaneously suppress NF-κB and activate p53 by targeting FACT. Sci Transl Med. 2011 Aug 10;3(95):95ra74. |
| Unit | Bottle |
| Specification | 2mg 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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