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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cytoskeleton > mL-7 HydrochlorideCAS：110448-33-4
Molecular Formula：C15H18ClIN2O2S
Molecular Weight：452.74
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 110448-33-4 |
| Name | mL-7 Hydrochloride |
| Molecular Formula | C15H18ClIN2O2S |
| Molecular Weight | 452.74 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00065524 |
| SMILES | O=S(N1CCNCCC1)(C2=C3C=CC=C(I)C3=CC=C2)=O.[H]Cl |
| Target Point | MLCK |
| Passage | Cytoskeleton |
| Background | mL-7 is a smooth muscle myosin light chain kinase mLCK inhibitor. |
| Biological Activity | ML7 may ameliorate VED and AS by regulating the TJ proteins ZO 1 and occludin via mechanisms involving MLCK and MLC phosphorylation.[1] |
| Data Literature Source | [1]. Cheng X，Wang X，Wan Y，Zhou Q，Zhu H，Wang Y. Myosin light chain kinase inhibitor ML7 improves vascular endothelial dysfunction via tight junction regulation in a rabbit model of atherosclerosis. Mol Med Rep. 2015 Sep;12(3):4109-4116. [2]. Connell LE，Helfman DM. Myosin light chain kinase plays a role in the regulation of epithelial cell survival. J Cell Sci. 2006 Jun 1;119(Pt 11):2269-81. |
| Unit | Bottle |
| Specification | 5mg 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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