| English Name |
Anti-MAPK15 Polyclonal Antibody |
| Chinese Name |
丝裂原激活的蛋白激酶15抗体 |
| Host |
Rabbit |
| Clone Type |
Polyclonal Antibody |
| Subtype |
IgG |
| Dilution Ratio |
IHC 1:50-200. |
| Target |
MAPK15 |
| Synonyms |
ERK-7, ERK-8, ERK7, ERK8, Extracellular regulated kinase 8 delta, Extracellular signal regulated kinase 8, Extracellular signal-regulated kinase 7, Extracellular signal-regulated kinase 8, MAP kinase 15, MAPK 15, Mapk15, Mitogen activated protein kinase 15, Mitogen-activated protein kinase 15, MK15_HUMAN |
| Background |
Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner. Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation. Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling. Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins. Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion. Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA. Regulates DA transporter (DAT) activity and protein expression via activation of RhoA. In response to H2O2 treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression. Also functions in a kinase activity-independent manner as a negative regulator of growth. Phosphorylates in vitro FOS and MBP. During oocyte maturation, plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes, fertilized eggs, and early embryos. Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity. |
| Swiss Prot |
Q8TD08 |
| Gene ID |
225689 |
| Subcellular Location |
Cytoplasm |
| Immunogen |
A synthetic peptide of human MAPK15 |
| Public Immunogen Range |
375-425/544aa |
| Calculated MW |
29/31/59kDa |
| Purification Method |
Affinity purification |
| Storage Buffer |
PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3. |
| Storage |
Store at -20℃. Avoid freeze/thaw cycles. |
| Piece |
Piece |
| Specification |
50ul 100ul |
| Reactivity |
Human |
| Application |
IHC |
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