English Name |
Anti-HDAC2 Polyclonal Antibody |
Chinese Name |
组蛋白去乙酰化酶 2抗体 |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Dilution Ratio |
WB 1:1000-3000. |
Target |
HDAC2 |
Synonyms |
histone deacetylase 2, D10Wsu179e, EC 3.5.1.98, HD2, HDAC 2, Hdac2, histone deacetylase 2, RPD3, transcriptional regulator homolog RPD3, YAF1, YY1 associated factor 1, YY1 transcription factor binding protein, Yy1bp, HDAC2_HUMAN |
Background |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A. |
Swiss Prot |
Q92769 |
Gene ID |
3066 |
Subcellular Location |
Nucleus |
Immunogen |
A synthetic peptide of human HDAC2 |
Public Immunogen Range |
365-415/488aa |
Calculated MW |
52/55kDa |
Purification Method |
Affinity purification |
Storage Buffer |
PBS with 50% Glycerol,0.03% Proclin300,0.5% BSA,pH 7.3. |
Storage |
Store at -20℃. Avoid freeze/thaw cycles. |
Piece |
Piece |
Specification |
50ul 100ul |
Reactivity |
Human Mouse |
Application |
WB |