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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > GSK-1070916CAS：942918-07-2
Molecular Formula：C30H33N7O
Molecular Weight：507.63
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 942918-07-2 |
| Name | GSK-1070916 |
| Molecular Formula | C30H33N7O |
| Molecular Weight | 507.63 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | O=C(NC1=CC=C(C2=NN(C=C2C3=C4C(NC(C5=CC=CC(CN(C)C)=C5)=C4)=NC=C3)CC)C=C1)N(C)C |
| Target Point | Aurora Kinase |
| Passage | Cell Cycle |
| Background | GSK-1070916 is a potent, selective, ATP-competitive inhibitor of Aurora B/C. |
| Biological Activity | GSK-1070916是有效，选择性，ATP竞争型的Aurora B/C抑制剂，Ki 值分别为0.38和1.5 nM[1-2]。 |
| Data Literature Source | [1]. Adams ND，et al. Discovery of GSK-1070916，a potent and selective inhibitor of Aurora B/C kinase. J Med Chem. 2010 May 27;53(10):3973-4001. [2]. Hardwicke MA，et al. GSK-1070916，a potent Aurora B/C kinase inhibitor with broad antitumor activity in tissue culture cells and human tumor xenograft models. Mol Cancer Ther. 2009 Jul;8(7):1808-17. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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