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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > PF-03814735CAS：942487-16-3
Molecular Formula：C23H25F3N6O2
Molecular Weight：474.48
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 942487-16-3 |
| Name | PF-03814735 |
| Molecular Formula | C23H25F3N6O2 |
| Molecular Weight | 474.48 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD16659065 |
| SMILES | O=C(CNC(C)=O)N1[C@@H]2C3=C(C=C(NC4=NC(NC5CCC5)=C(C(F)(F)F)C=N4)C=C3)[C@H]1CC2 |
| Target Point | FAK;FLT1;AuroraA，AuroraB;TrkA |
| Passage | Cell Cycle |
| Background | PF-03814735 is a potent, reversible inhibitor of Aurora A/B. |
| Biological Activity | PF-03814735是有效, 可逆的极光激酶A和B (aurora A/B) 的抑制剂, IC50值分别为0.8和5 nM[1-2]。 |
| IC50 | Aurora 1:0.8nM (IC50) Aurora 2:5nM (IC50) Flt-1:10nM (IC50) FAK:22nM (IC50) TrkA:30nM (IC50)met:100nM (IC50) FGFR1:100nM (IC50) [1-2] |
| Data Literature Source | [1]. Jani JP， et al. PF-03814735， an orally bioavailable small molecule aurora kinase inhibitor for cancer therapy. Mol Cancer Ther. 2010 Apr; 9 (4) :883-94. [2]. Hook KE， et al. An integrated genomic approach to identify predictive biomarkers of response to the aurora kinase inhibitor PF-03814735. Mol Cancer Ther. 2012 Mar; 11 (3) :710-9 |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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