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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > TAME HydrochlorideCAS：1784-03-8
Molecular Formula：C14H22N4O4S·HCl
Molecular Weight：378.87
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1784-03-8 |
| Name | TAME Hydrochloride |
| Molecular Formula | C14H22N4O4S·HCl |
| Molecular Weight | 378.87 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 217-235-1 |
| MDL | MFCD00012578 |
| SMILES | CC1=CC=C(C=C1)S(N[C@H](C(OC)=O)CCCNC(N)=N)(=O)=O.[H]Cl |
| Target Point | APC |
| Passage | CellCycle |
| Background | TAME hydrochloride is an activated protein C (APC) inhibitor that inhibits APC activity by acting on Cdc20 and Cdh1. |
| Biological Activity | TAME hydrochloride 是一种活化蛋白 C (APC) 抑制剂，可通过作用于 Cdc20 和 Cdh1 来抑制 APC 的活性。[1-3] |
| Data Literature Source | [1]. Zeng X，et al. Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. Cancer Cell. 2010 Oct 19;18(4):382-95. [2]. Zeng X，et al. An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination. Nat Chem Biol. 2012 Feb 26;8(4):383-92. [3]. Ma Y，et al. Differential effects of Mg(ii) and N(alpha)-4-tosyl-l-arginine methyl ester hydrochloride on the recognition and catalysis in ATP hydrolysis. Dalton Trans. 2008 Feb 28;(8):1081-6. |
| Unit | Bottle |
| Specification | 10mg 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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