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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > MK-8776CAS：891494-63-6
Molecular Formula：C15H18BrN7
Molecular Weight：376.25
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 891494-63-6 |
| Name | MK-8776 |
| Molecular Formula | C15H18BrN7 |
| Molecular Weight | 376.25 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00001813 |
| SMILES | NC1=C(Br)C([C@H]2CNCCC2)=NC3=C(C4=CN(C)N=C4)C=NN13 |
| Target Point | Checkpoint Kinase (Chk) |
| Passage | Cell Cycle |
| Background | SCH900776 is a potent and selective Chk1 inhibitor. |
| Biological Activity | MK-8776是一种有效，选择性，可口服的 Chk1 抑制剂，IC50 值为 3 nM；它比对CDK2 和 Chk2 的选择性分别高50和500倍。[1-2] |
| IC50 | Chk1:3nM;Chk2:1500nM;CDK2:160nM [1-2] |
| Data Literature Source | [1]. Montano R，et al. Preclinical development of the novel Chk1 inhibitor SCH900776 in combination with DNA-damaging agents and antimetabolites. Mol Cancer Ther. 2012 Feb;11(2):427-38. [2]. Guzi TJ，et al. Targeting the replication checkpoint using SCH 900776，a potent and functionally selective CHK1 inhibitor identified via high content screening. Mol Cancer Ther. 2011 Apr;10(4):591-602 |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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