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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cytoskeleton > Ripasudil Hydrochloride DihydrateCAS：887375-67-9
Molecular Formula：C15H23ClFN3O4S
Molecular Weight：395.88
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 887375-67-9 |
| Name | Ripasudil Hydrochloride Dihydrate |
| Molecular Formula | C15H23ClFN3O4S |
| Molecular Weight | 395.88 |
| Solubility | Soluble in Water |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD26960897 |
| SMILES | FC1=CN=CC2=C1C(S(N3CCCNC[C@@H]3C)(=O)=O)=CC=C2.[H]Cl.O.O |
| Target Point | ROCK |
| Passage | Cytoskeleton; Cell Cycle;TGF-beta/Smad;Stem Cells |
| Background | Ripasudil Hydrochloride Dihydrate is a potent ROCK inhibitor |
| Biological Activity | Ripasudil (K-115) is a specific inhibitor of ROCK， with IC50s of 19 and 51 nM for ROCK2 and ROCK1， respectively.[1-3] |
| Data Literature Source | [1]. Isobe T， et al. Effects of K-115， a rho-kinase inhibitor， on aqueous humor dynamics in rabbits. Curr Eye Res. 2014 Aug;39(8):813-22. [2]. Kaneko Y， et al. Effects of K-115 (Ripasudil)， a novel ROCK inhibitor， on trabecular meshwork and Schlemms canal endothelial cells. Sci Rep. 2016 Jan 19;6:19640. [3]. Yamamoto K， et al. The novel Rho kinase (ROCK) inhibitor K-115: a new candidate drug for neuroprotective treatment in glaucoma. Invest Ophthalmol Vis Sci. 2014 Oct 2;55(11):7126-36. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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