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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > MK-8745CAS：885325-71-3
Molecular Formula：C20H19ClFN5OS
Molecular Weight：431.91
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 885325-71-3 |
| Name | MK-8745 |
| Molecular Formula | C20H19ClFN5OS |
| Molecular Weight | 431.91 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | O=C(C1=CC=CC(Cl)=C1F)N2CCN(CC3=NC(NC4=NC=CS4)=CC=C3)CC2 |
| Target Point | Aurora Kinase inhibitor |
| Passage | Cell Cycle |
| Background | MK-8745 is Aurora A. |
| Biological Activity | MK-8745是极光激酶抑制剂 (aurora A)，IC50 值为0.6 nM。[1-2] |
| Data Literature Source | [1]. Jayasree S Nair et al. The induction of polyploidy or apoptosis by the Aurora A kinase inhibitor MK8745 is p53-dependent. [2]. Aparajita Chowdhury et al. A novel Aurora kinase A inhibitor MK-8745 predictsTPX2 as a therapeutic biomarker in non-Hodgkin lymphoma cell lines.Leuk Lymphoma，2012 Mar，53(3):462-71. |
| Unit | Bottle |
| Specification | 5mg 10mg 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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