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mL-141

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Cat.No：IM2250 Solarbio

CAS：71203-35-5

Molecular Formula：C₂₂H₂₁N₃O₃S

Molecular Weight：407.49

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	71203-35-5
Name	mL-141
Molecular Formula	C₂₂H₂₁N₃O₃S
Molecular Weight	407.49
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD05987165
SMILES	O=S(C1=CC=C(N2N=C(C3=CC=CC=C3)CC2C4=CC=C(OC)C=C4)C=C1)(N)=O
Target Point	Ras；Cdc42 GTPase
Passage	Cell Cycle; GPCR & G Protein
Background	mL141 is a potent and selective inhibitor of Cdc42.
Biological Activity	ML141 (CID-2950007) 是 Rho 家族GTPase cdc42的一种有效的，选择性可逆非竞争性抑制剂，IC50为200 nM。对cdc42比对其他Rho家族中的GTPases(如Rac1, Rab2, Rab7)更有选择性。 ML141 与 p38 激活增加有关，并可能诱导p38依赖性凋亡/衰老。ML141还可保护神经母细胞瘤细胞免受二甲双胍(metformin)诱导的凋亡。[1-5]
IC50	cdc42: 200nM[1]
Data Literature Source	[1] Surviladze Z，et al. National Center for Biotechnology Information (US); 2010. [2] Chen HY，et al. EMBO Mol Med. 2013，5(5)，723-736. [3] Kumar A，et al. Oncotarget. 2014，5(22)，11709-11722. [4] Hsu CR，et al. Infect Immun. 2014. pii: IAI.02345-14. [5] Chen C，et al. DOI10.1007/s12185-014-1690-z.
Unit	Bottle
Specification	5mg 10mM*1mL in DMSO 10mg 25mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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