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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > Chk2 Inhibitor ⅡCAS：516480-79-8
Molecular Formula：C20H14ClN3O2
Molecular Weight：363.8
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 516480-79-8 |
| Name | Chk2 Inhibitor Ⅱ |
| Molecular Formula | C20H14ClN3O2 |
| Molecular Weight | 363.8 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD08276917 |
| SMILES | ClC(C=C1)=CC=C1OC(C=C2)=CC=C2C3=NC4=CC(C(N)=O)=CC=C4N3 |
| Target Point | Checkpoint Kinase (Chk) |
| Passage | Cell Cycle |
| Background | Chk2 Inhibitor Ⅱ is an ATP-competitive inhibitor of Chk2. |
| Biological Activity | 是一种Chk2的ATP竞争性抑制剂，IC50为15 nM。它对Chk2的选择性比对Chk1和Cdk1/B激酶高1000倍以上。Chk2 Inhibitor II (BML-277) 剂量依赖性地保护人CD4(+)和CD8(+)T细胞免受电离辐射导致的凋亡。[1-2] |
| IC50 | Chk2(Cell-free assay): 15nM [1] |
| Data Literature Source | [1] Arienti KL，et al. J Med Chem. 2005，48(6):1873-85. [2] Dai B，et al. Nat Commun. 2011，2:402. |
| Unit | Bottle |
| Specification | 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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