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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > SU-9516CAS：377090-84-1
Molecular Formula：C13H11N3O2
Molecular Weight：241.25
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light brown to brown Solid
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| CAS | 377090-84-1 |
| Name | SU-9516 |
| Molecular Formula | C13H11N3O2 |
| Molecular Weight | 241.25 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light brown to brown Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD17010284 |
| SMILES | O=C1NC2=C(C=C(OC)C=C2)/C1=C/C3=CN=CN3 |
| Target Point | CDK |
| Passage | Cell Cycle |
| Background | SU9516 is a potent CDK2 inhibitor. |
| Biological Activity | SU9516 是一种有效的 CDK2 抑制剂，IC50 值为 22 nM，同时对 CDK1 和 CDK4 也有抑制作用，IC50 值分别为 40 和 200 nM。[1-3] |
| Data Literature Source | [1]. Lane ME，et al. A novel cdk2-selective inhibitor，SU9516，induces apoptosis in colon carcinoma cells. Cancer Res. 2001 Aug 15;61(16):6170-7. [2]. Yu B，et al. SU9516，a cyclin-dependent kinase 2 inhibitor，promotes accumulation of high molecular weight E2F complexes in human colon carcinoma cells. Biochem Pharmacol. 2002 Oct 1;64(7):1091-100. [3]. Gao N，et al. The three-substituted indolinone cyclin-dependent kinase 2 inhibitor 3-[1-(3H-imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1，3-dihydro-indol-2-one (SU9516) kills human leukemia cells via down-regulation of Mcl-1 through a transcriptional mechanism. Mol Pharmacol. 2006 Aug;70(2):645-55 |
| Unit | Bottle |
| Specification | 5mg 10mg 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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