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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > GPCR & G Protein > AM 251CAS：183232-66-8
Molecular Formula：C22H21Cl2IN4O
Molecular Weight：555.24
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 183232-66-8 |
| Name | AM 251 |
| Molecular Formula | C22H21Cl2IN4O |
| Molecular Weight | 555.24 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD01861181 |
| SMILES | O=C(C1=NN(C2=CC=C(Cl)C=C2Cl)C(C3=CC=C(I)C=C3)=C1C)NN4CCCCC4 |
| InChIKey | BUZAJRPLUGXRAB-UHFFFAOYSA-N |
| InChI | InChI=1S/C22H21Cl2IN4O/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-7-16(23)13-18(19)24)21(14)15-5-8-17(25)9-6-15/h5-10,13H,2-4,11-12H2,1H3,(H,27,30) |
| PubChem CID | 2125 |
| Target Point | Cannabinoid Receptor antagonist |
| Passage | GPCR & G Protein;Neuronal Signaling |
| Background | AM251 is a selective CB1 receptor antagonist. |
| Biological Activity | AM251是选择性大麻素1 (CB1) 受体拮抗剂，IC50 为8 nM。AM251也是 GPR55 的激动剂，EC50为39 nM[1-7]。 |
| IC50 | 8nM(CB1 receptor)[1] |
| Data Literature Source | [1]. Bruno A，et al. Beyond radio-displacement techniques for identification of CB1 ligands: the first application of afluorescence-quenching assay. Sci Rep. 2014 Jan 20;4:3757. [2]. Sharir H，et al. Pharmacological characterization of GPR55，a putative cannabinoid receptor. Pharmacol Ther. 2010 Jun;126(3):301-13. [3]. Thewke D，et al. AM-251 and SR144528 are acyl CoA:cholesterol acyltransferase inhibitors. Biochem Biophys Res Commun. 2009 Apr 3;381(2):181-6. [4]. Carey LM，et al. A pro-nociceptive phenotype unmasked in mice lacking fatty-acid amide hydrolase. Mol Pain. 2016 May 13;12. pii: 1744806916649192. [5]. Komaki A，et al. Study the Effect of Endocannabinoid System on Rat Behavior in Elevated Plus-Maze. Basic Clin Neurosci. 2015 Jul;6(3):147-53. [6]. Jiang X，et al. Role of cannabinoid receptor type 1 in tibial and pudendal neuromodulation of bladder overactivity in cats. Am J Physiol Renal Physiol. 2017 Mar 1;312(3):F482-F488. [7]. Sun L，et al. Endocannabinoid activation of CB1 receptors contributes to long-lasting reversal of neuropathic pain by repetitive spinal cord stimulation. Eur J Pain. 2017 May;21(5):804-814. |
| Unit | Bottle |
| Specification | 5mg 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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