| English Name |
Anti-FYN Polyclonal Antibody |
| Chinese Name |
与 SRC、FGR、YES 相关的 FYN 癌基因抗体 |
| Host |
Rabbit |
| Clone Type |
Polyclonal Antibody |
| Subtype |
IgG |
| Dilution Ratio |
IHC 1:100-300. |
| Target |
FYN |
| Synonyms |
Fyn, C syn protooncogene, FYN oncogene related to SRC FGR YES, MGC45350, OKT3 induced calcium influx regulator, P59 FYN, Protein tyrosine kinase fyn, Proto oncogene tyrosine protein kinase fyn, Protooncogene Syn, SLK, Src like kinase, Src yes related novel gene, Src/yes related novel gene,SYN, Tyrosine kinase p59fyn T, Tyrosine kinase p59fyn(T), FYN_HUMAN, Tyrosine-protein kinase Fyn, Proto-oncogene Syn, Proto-oncogene c-Fyn, Src-like kinase, p59-Fyn |
| Background |
Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1. In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling. |
| Swiss Prot |
P06241 |
| Gene ID |
2534 |
| Subcellular Location |
Cell membrane Cytoplasm |
| Immunogen |
A synthetic peptide of human FYN |
| Public Immunogen Range |
15-65/537aa |
| Calculated MW |
54/60/61kDa |
| Purification Method |
Octanoic acid-ammonium sulfate precipitation |
| Storage Buffer |
PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3. |
| Storage |
Store at -20℃. Avoid freeze/thaw cycles. |
| Piece |
Piece |
| Specification |
50ul 100ul |
| Reactivity |
Human Rat Mouse |
| Application |
IHC |
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