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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > AZ-3146CAS：1124329-14-1
Molecular Formula：C24H32N6O3
Molecular Weight：452.55
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Off-white to yellow Solid
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| CAS | 1124329-14-1 |
| Name | AZ-3146 |
| Molecular Formula | C24H32N6O3 |
| Molecular Weight | 452.55 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Off-white to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD18384959 |
| SMILES | CN(CC1)CCC1OC2=CC=C(NC3=NC(N(C4CCCC4)C(N5C)=O)=C5C=N3)C(OC)=C2 |
| Target Point | Mps1 |
| Passage | Cell Cycle; Cytoskeleton |
| Background | AZ 3146 is a selective Mps1 inhibitor. |
| Biological Activity | AZ3146 是一种有效的选择性的 Mps1 抑制剂, 作用于 Mps1Cat, IC50 为 35 nM[1-3]。 |
| IC50 | Mps1Cat:35nM (IC50) [1-3] |
| Data Literature Source | [1]. Hewitt L， et al. Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex. J Cell Biol. 2010 Jul 12; 190 (1) :25-34. [2]. Liu X， et al. TTK activates Akt and promotes proliferation and migration of hepatocellular carcinoma cells. Oncotarget. 2015 Oct 27; 6 (33) :34309-20. [3]. Gurden MD， et al. Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. Cancer Res. 2015 Aug 15; 75 (16) :3340-54. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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