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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > Cytarabine HydrochlorideCAS：69-74-9
Molecular Formula：C9H13N3O5·HCl
Molecular Weight：279.68
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥97%
Appearance：White to off-white Solid
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| CAS | 69-74-9 |
| Name | Cytarabine Hydrochloride |
| Molecular Formula | C9H13N3O5·HCl |
| Molecular Weight | 279.68 |
| Solubility | Soluble in DMSO |
| Purity | ≥97% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-713-9 |
| MDL | MFCD00012839 |
| SMILES | O=C1N=C(N)C=CN1[C@H]2[C@H]([C@@H]([C@@H](CO)O2)O)O.Cl |
| InChIKey | KCURWTAZOZXKSJ-JBMRGDGGSA-N |
| InChI | InChI=1S/C9H13N3O5.ClH/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8;/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16);1H/t4-,6-,7+,8-;/m1./s1 |
| PubChem CID | 6252 |
| Target Point | DNA/RNA Synthesis |
| Passage | Cell Cycle;DNA Damage/DNA Repair |
| Background | Cytarabine Hydrochloride has anti-metabolic and anti-DNA synthesis activity. |
| Biological Activity | Cytarabine (AraC)盐酸盐具有抗代谢和抗DNA合成活性。[1-4] |
| Data Literature Source | [1]. Tobias，S.C. and R.F. Borch，Synthesis and biological evaluation of a cytarabine phosphoramidate prodrug. Mol Pharm，2004. 1(2): p. 112-6. [2]. Besirli，C.G.，et al. Cytosine arabinoside rapidly activates Bax-dependent apoptosis and a delayed Bax-independent death pathway in sympathetic neurons. Cell Death Differ，2003. 10(9): p. 1045-58. [3]. Yamauchi，H.，et al.，Involvement of p53 in 1-beta-D-arabinofuranosylcytosine-induced trophoblastic cell apoptosis and impaired proliferation in rat placenta. Biol Reprod，2004. 70(6): p. 1762-7. [4]. Richel，D.J.，et al.，Comparison of the antileukaemic activity of 5 aza-2-deoxycytidine and arabinofuranosyl-cytosine in rats with myelocytic leukaemia. Br J Cancer，1988. 58(6): p. 730-3 |
| Unit | Bottle |
| Specification | 100mg 10mM*1mL in DMSO 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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