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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > Flavopiridol HydrochlorideCAS：131740-09-5
Molecular Formula：C21H20ClNO5·HCl
Molecular Weight：438.3
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to brown Solid
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| CAS | 131740-09-5 |
| Name | Flavopiridol Hydrochloride |
| Molecular Formula | C21H20ClNO5·HCl |
| Molecular Weight | 438.3 |
| Solubility | Soluble in Water/DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to brown Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 634-346-4 |
| MDL | MFCD26792554 |
| SMILES | O=C1C2=C(C=C(C([C@]3([H])[C@H](O)CN(C)CC3)=C2OC(C4=CC=CC=C4Cl)=C1)O)O.[H]Cl |
| Target Point | CDK12,4,6,7 |
| Passage | Cell Cycle |
| Background | Flavopiridol HCl competitively inhibits CDKs with ATP. |
| Biological Activity | Flavopiridol Hydrochloride 是一种 CDK 的广谱抑制剂，与 ATP 竞争性地抑制 CDK1，CDK2 和 CDK4 的活性，IC50 值分别为 30, 170, 100 nM[1-3]。 |
| IC50 | IC50：:30nM(CDK1/Cyc B1);170nM(CDK2/Cyc E);100nM(CDK4/Cyc D1)[1-3] |
| Data Literature Source | [1]. Mahoney E，et al. ER stress and autophagy: new discoveries in the mechanism of action and drug resistance of the cyclin-dependent kinase inhibitor flavopiridol.Blood. 2012 Aug 9;120(6):1262-1273. [2]. Keskin H，et al. Complex effects of flavopiridol on the expression of primary response genes. Cell Div. 2012 Mar 29;7:11. [3]. Kim KS，et al.Thio- and oxoflavopiridols，cyclin-dependent kinase 1-selective inhibitors: synthesis and biological effects. J Med Chem. 2000 Nov 2;43(22):4126-34. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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