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Geldanamycin

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Cat.No：IG2330 Solarbio

CAS：30562-34-6

Molecular Formula：C₂₉H₄₀N₂O₉

Molecular Weight：560.64

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Solid

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Product Information

CAS	30562-34-6
Name	Geldanamycin
Molecular Formula	C₂₉H₄₀N₂O₉
Molecular Weight	560.64
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD00274570
SMILES	COC(C(C=C1NC(/C(C)=C/C=C/[C@H](OC)[C@@H](OC(N)=O)/C(C)=C/[C@H](C)[C@H]2O)=O)=O)=C(C[C@H](C[C@@H]2OC)C)C1=O
Target Point	HSP90
Passage	Cell Cycle;Metabolic Enzyme&Protease
Background	Geldanamycin is an HSP90 inhibitor.
Biological Activity	Geldanamycin是 Hsp90 抑制剂，具有抗许多革兰氏阳性和一些革兰氏阴性细菌的活性。[1-4]
Data Literature Source	[1]. Tang HB，et al. Viperin inhibits rabies virus replication via reduced cholesterol and sphingomyelin and is regulated upstream by TLR4. Sci Rep. 2016 Jul 26;6:30529 [2]. Chen WW，et al. RIP1 mediates the protection of Geldanamycin on neuronal injury induced by oxygen-glucosedeprivation combined with zVAD in primary cortical neurons. J Neurochem. 2012 Jan;120(1):70-7. [3]. Lin Z，et al. 17-ABAG，a novel Geldanamycin derivative，inhibits LNCaP-cell proliferation through heat shock protein 90 inhibition. Int J Mol Med. 2015 Aug;36(2):424-32. [4]. Roe SM，et al. Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin. J Med Chem. 1999 Jan 28;42(2):260-6.
Unit	Bottle
Specification	2mg 5mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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