{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > DNA Damage & DNA Repai > Givinostat Hydrochloride MonohydrateCAS：732302-99-7
Molecular Formula：C24H27N3O4·HCl·H2O
Molecular Weight：475.97
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 732302-99-7 |
| Name | Givinostat Hydrochloride Monohydrate |
| Molecular Formula | C24H27N3O4·HCl·H2O |
| Molecular Weight | 475.97 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-258-5 |
| MDL | MFCD28502062 |
| SMILES | O=C(OCC1=CC=C2C=C(CN(CC)CC)C=CC2=C1)NC3=CC=C(C(NO)=O)C=C3.[H]Cl.O |
| Target Point | HDAC |
| Passage | DNA Damage/DNA Repair;Epigenetics;NF-κB |
| Background | Givinostat Hydrochloride Monohydrate is a potent HDAC inhibitor. |
| Biological Activity | Givinostat hydrochloride monohydrate 是 HDAC 抑制剂, 抑制 HDAC1 和 HDAC3, IC50 分别为 198 nM 和 157 nM[1-3]。 |
| IC50 | hHDAC3:157nM (IC50) hHDAC1:198nM (IC50) hHDAC11:292nM (IC50) hHDAC6:315nM (IC50) hHDAC2:325nM (IC50) hHDAC10:340nM (IC50) hHDAC7:524nM (IC50) hHDAC5:532nM (IC50) hHDAC9:541nM (IC50) hHDAC8:854nM (IC50) hHDAC4:1059nM (IC50) HD1-B:7.5nM (IC50) HD1-A:16nM (IC50) HD2:10nM (IC50) [1-3] |
| Data Literature Source | [1]. Li S， et al. Specific inhibition of histone deacetylase 8 reduces gene expression and production of proinflammatory cytokines in vitro and in vivo. J Biol Chem. 2015 Jan 23; 290 (4) :2368-78. [2]. Wang YG， et al. Givinostat inhibition of hepatic stellate cell proliferation and protein acetylation. World J Gastroenterol. 2015 Jul 21; 21 (27) :8326-39. [3]. Leoni F， et al. The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo. Mol Med. 2005 Jan-Dec; 11 (1-12) :1-15. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
