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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > IPA-3CAS：42521-82-4
Molecular Formula：C20H14O2S2
Molecular Weight：350.45
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 42521-82-4 |
| Name | IPA-3 |
| Molecular Formula | C20H14O2S2 |
| Molecular Weight | 350.45 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00388917 |
| SMILES | OC1=CC=C2C=CC=CC2=C1SSC3=C4C=CC=CC4=CC=C3O |
| Target Point | PAK1 |
| Passage | Cell Cycle; Cytoskeleton |
| Background | IPA-3 is a selective, non-ATP-competitive inhibitor of Pak1. |
| Biological Activity | IPA-3 是一种选择性的，ATP 非竞争的 PAK1 抑制剂，IC50 值为 2.5 μM，对 PAKs 4-6 没有抑制作用。[1-3] |
| IC50 | PAK1:2.5μM [1-3] |
| Data Literature Source | [1]. Viaud J，et al. An allosteric kinase inhibitor binds the p21-activated kinase autoregulatory domain covalently. Mol Cancer Ther. 2009 Sep;8(9):2559-65. [2]. Flaiz C，et al. PAK kinase regulates Rac GTPase and is a potential target in human schwannomas. Exp Neurol. 2009 Jul;218(1):137-44. [3]. Deacon SW，et al. An isoform-selective，small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase. Chem Biol. 2008 Apr;15(4):322-31. |
| Unit | Bottle |
| Specification | 5mg 10mg 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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