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M-344

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Cat.No：IM2530 Solarbio

CAS：251456-60-7

Molecular Formula：C₁₆H₂₅N₃O₃

Molecular Weight：307.39

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	251456-60-7
Name	M-344
Molecular Formula	C₁₆H₂₅N₃O₃
Molecular Weight	307.39
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD03453554
SMILES	O=C(NCCCCCCC(NO)=O)C1=CC=C(N(C)C)C=C1
InChIKey	MXWDSZWTBOCWBK-UHFFFAOYSA-N
InChI	InChI=1S/C16H25N3O3/c1-19(2)14-10-8-13(9-11-14)16(21)17-12-6-4-3-5-7-15(20)18-22/h8-11,22H,3-7,12H2,1-2H3,(H,17,21)(H,18,20)
PubChem CID	3994
Target Point	HDAC
Passage	DNA Damage/DNA Repair;Epigenetics;NF-κB
Background	M344 is a potent HDAC inhibitor.
Biological Activity	M344 (D 237) 是一种组蛋白去乙酰化酶（HDAC）抑制剂，IC50 为 100 nM。[1-2]
IC50	HDAC:100nM [1-2]
Data Literature Source	[1]. Jung M1，et al. Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation. J Med Chem. 1999 Nov 4;42(22):4669-79. [2]. Weberpals JI，et al. The effect of the histone deacetylase inhibitor M344 on BRCA1 expression in breast and ovarian cancer cells. Cancer Cell Int. 2011 Aug 19;11(1):29
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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