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Mdivi-1

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Cat.No：IM2550 Solarbio

CAS：338967-87-6

Molecular Formula：C₁₅H₁₀Cl₂N₂O₂S

Molecular Weight：353.22

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to brown Solid

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Product Information

CAS	338967-87-6
Name	Mdivi-1
Molecular Formula	C₁₅H₁₀Cl₂N₂O₂S
Molecular Weight	353.22
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to brown Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD00974506
SMILES	O=C1N(C2=C(Cl)C=C(Cl)C(OC)=C2)C(S)=NC3=C1C=CC=C3
Target Point	Dynamin
Passage	Cytoskeleton
Background	Mdivi-1 is a potent mitochondrial division/mitophagy inhibitor that inhibits DRP1 (motor protein-associated GTPase) and Dynamin I (Dnm1) activity.
Biological Activity	Mdivi-1是选择性的发动蛋白相关蛋白1 (Drp1) 抑制剂。Mdivi-1以剂量依赖性方式抑制Dnm1 GTP酶活性，估计EC50为1-10μM。[1-4]
Data Literature Source	[1]. Cassidy-Stone A，et al. Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. Dev Cell. 2008 Feb;14(2):193-204. [2]. Tanaka A，et al. A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis. Mol Cell. 2008 Feb 29;29(4):409-10. [3]. Park SW，et al. A selective inhibitor of drp1，mdivi-1，increases retinal ganglion cell survival in acute ischemic mouse retina. Invest Ophthalmol Vis Sci. 2011 Apr 27;52(5):2837-43. [4]. Zhou K，et al. RIP1-RIP3-DRP1 pathway regulates NLRP3 inflammasome activation following subarachnoid hemorrhage. Exp Neurol. 2017 Sep;295:116-124.
Unit	Bottle
Specification	10mg 10mM*1mL in DMSO 20mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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