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PF-04928473

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Cat.No：IP3220 Solarbio

CAS：908112-43-6

Molecular Formula：C₂₃H₂₇F₃N₄O₃

Molecular Weight：464.48

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Solid

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Product Information

CAS	908112-43-6
Name	PF-04928473
Molecular Formula	C₂₃H₂₇F₃N₄O₃
Molecular Weight	464.48
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD16038907
SMILES	O=C1CC(C)(C)CC2=C1C(C(F)(F)F)=NN2C3=CC=C(C(N[C@H]4CC[C@@H](CC4)O)=C3)C(N)=O
Target Point	HSP
Passage	Cell Cycle;Metabolic Enzyme&Protease
Background	SNX-2112 is an Hsp90 inhibitor.
Biological Activity	SNX-2112 是一种可口服的 Hsp90 抑制剂，Kd 值为 16 nM，对 Hsp90 α 和 Hsp90β 的 IC50 值均为 30 nM；同时可诱导 Her-2 的降解，抑制 Grp94 和 Trap-1 的活性，IC50 值分别为 10 nM，4.275 μM 和 0.862 μM。[1-3]
IC50	HSP90α:30nM;HSP90β:30nM [2]
Data Literature Source	[1]. Huang KH，et al. Discovery of novel 2-aminobenzamide inhibitors of heat shock protein 90 as potent，selective and orally active antitumor agents. J Med Chem. 2009 Jul 23;52(14):4288-305 [2]. Chandarlapaty S，et al. SNX2112，a synthetic heat shock protein 90 inhibitor，has potent antitumor activity against HER kinase-dependent cancers. Clin Cancer Res. 2008 Jan 1;14(1):240-8. [3]. Okawa Y，et al. SNX-2112，a selective Hsp90 inhibitor，potently inhibits tumor cell growth，angiogenesis，and osteoclastogenesis in multiple myeloma and other hematologic tumors by abrogating signaling via Akt and ERK. Blood. 2009 Jan 22;113(4):846-55.
Unit	Bottle
Specification	2mg 5mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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