{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > PF-04929113CAS：908115-27-5
Molecular Formula：C25H30F3N5O4
Molecular Weight：521.53
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥97%
Appearance：Solid
Qty：
Size：
| CAS | 908115-27-5 |
| Name | PF-04929113 |
| Molecular Formula | C25H30F3N5O4 |
| Molecular Weight | 521.53 |
| Solubility | Soluble in DMSO |
| Purity | ≥97% |
| Appearance | Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD20526334 |
| SMILES | O=C1CC(C)(C)CC2=C1C(C(F)(F)F)=NN2C3=CC=C(C(N[C@@H]4CC[C@@H](OC(CN)=O)CC4)=C3)C(N)=O |
| Target Point | HSP |
| Passage | Cell Cycle;Metabolic Enzyme&Protease |
| Background | PF-04929113 is a potent and selective HSP90 inhibitor. |
| Biological Activity | SNX-5422 (PF-04929113) 是 SNX-2112 的前体药物，为可口服的 Hsp90 抑制剂，Kd 值为 41 nM，同时可诱导 Her-2 的降解，IC50 值为 37 nM。[1-3] |
| Data Literature Source | [1]. Huang KH，et al. Discovery of novel 2-aminobenzamide inhibitors of heat shock protein 90 as potent，selective and orally active antitumor agents. J Med Chem. 2009 Jul 23;52(14):4288-305 [2]. Chandarlapaty S，et al. SNX2112，a synthetic heat shock protein 90 inhibitor，has potent antitumor activity against HER kinase-dependent cancers. Clin Cancer Res. 2008 Jan 1;14(1):240-8. [3]. Kim SH，et al. The heat shock protein 90 inhibitor SNX5422 has a synergistic activity with histone deacetylase inhibitors in induction of death of anaplastic thyroid carcinoma cells. Endocrine. 2016 Feb;51(2):274-82. |
| Unit | Bottle |
| Specification | 2mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
