Your Position: Home > Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > PU-H71

PU-H71

Manual Download

Cat.No：IP3280 Solarbio

CAS：873436-91-0

Molecular Formula：C₁₈H₂₁IN₆O₂S

Molecular Weight：512.37

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Solid

Qty：

Size：

Add to cart

Product Information Experimental Images Related Products Related Paper Technical Q&A

Product Information

CAS	873436-91-0
Name	PU-H71
Molecular Formula	C₁₈H₂₁IN₆O₂S
Molecular Weight	512.37
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD18251588
SMILES	CC(C)NCCCN1C(SC2=C(C=C3OCOC3=C2)I)=NC4=C(N=CN=C14)N
Target Point	HSP
Passage	Cell Cycle;Metabolic Enzyme&Protease
Background	PU-H71 is a potent and selective HSP90 inhibitor.
Biological Activity	PU-H71 是一种有效的 Hsp90 抑制剂，在 MDA-MB-468 细胞中，对 Hsp90 的 IC50 值为 51 nM。[1-3]
Data Literature Source	[1]. Caldas-Lopes E，et al. Hsp90 inhibitor PU-H71，a multimodal inhibitor of malignancy，induces complete responses in triple-negative breast cancer models. Proc Natl Acad Sci U S A. 2009 May 19;106(20):8368-73. [2]. Guo A，et al. HSP90 stabilizes B-cell receptor kinases in a multi-client interactome: PU-H71 induces CLL apoptosis in a cytoprotective microenvironment. Oncogene. 2017 Jun 15;36(24):3441-3449. [3]. Qu Z，et al. PU-H71 effectively induces degradation of IκB kinase β in the presence of TNF-α. Mol Cell Biochem. 2014 Jan;386(1-2):135-42.
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

Note：

1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.

2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.

3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.