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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cytoskeleton > RKI-1447CAS：1342278-01-6
Molecular Formula：C16H14N4O2S
Molecular Weight：326.37
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1342278-01-6 |
| Name | RKI-1447 |
| Molecular Formula | C16H14N4O2S |
| Molecular Weight | 326.37 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-256-5 |
| MDL | MFCD26142658 |
| SMILES | O=C(NC1=NC(C2=CC=NC=C2)=CS1)NCC3=CC=CC(O)=C3 |
| Target Point | ROCK |
| Passage | Cytoskeleton; Cell Cycle;TGF-beta/Smad;Stem Cells |
| Background | RKI-1447 is a potent ROCK1 and ROCK2 inhibitor. |
| Biological Activity | RKI-1447是高效的ROCK1和ROCK2的小分子抑制剂，IC50值分别为14.5 nM 和6.2 nM。[1] |
| IC50 | ROCK2:6.2nM;ROCK1:14.5nM [1] |
| Data Literature Source | [1]. Patel RA，et al. RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer. Cancer Res. 2012 Oct 1;72(19):5025-34. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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