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Salirasib

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Cat.No：IS2090 Solarbio

CAS：162520-00-5

Molecular Formula：C₂₂H₃₀O₂S

Molecular Weight：358.54

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to yellow Solid

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Product Information

CAS	162520-00-5
Name	Salirasib
Molecular Formula	C₂₂H₃₀O₂S
Molecular Weight	358.54
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD00467723
SMILES	O=C(O)C1=CC=CC=C1SC/C=C(C)/CC/C=C(C)/CC/C=C(C)/C
Target Point	Ras
Passage	Cell Cycle; GPCR & G Protein
Background	It is a Ras inhibitor.
Biological Activity	Salirasib是一种 Ras 抑制剂，可特异性抑制致癌激活的Ras和生长因子受体介导的Ras激活，从而抑制Ras依赖性肿瘤生长。[1-3]
Data Literature Source	[1]. Makovski V，et al. Farnesylthiosalicylic acid (salirasib) inhibits Rheb in TSC2-null ELT3 cells: a potential treatment for lymphangioleiomyomatosis. Int J Cancer. 2012 Mar 15;130(6):1420-9. [2]. Nevo Y，et al. Chapman J. The Ras antagonist，farnesylthiosalicylic acid (FTS)，decreases fibrosis and improves muscle strength in dy/dy mouse model of muscular dystrophy. PLoS One. 2011 Mar 22;6(3):e18049. [3]. Charette N，et al. Salirasib inhibits the growth of hepatocarcinoma cell lines in vitro and tumor growth in vivo through ras and mTOR inhibition. Mol Cancer. 2010 Sep 22;9:256.
Unit	Bottle
Specification	10mg 50mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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