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SBE-13 Hydrochloride

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Cat.No：IS2110 Solarbio

CAS：1052532-15-6

Molecular Formula：C₂₄H₂₇ClN₂O₄·HCl

Molecular Weight：479.4

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Light yellow to yellow Solid

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Product Information

CAS	1052532-15-6
Name	SBE-13 Hydrochloride
Molecular Formula	C₂₄H₂₇ClN₂O₄·HCl
Molecular Weight	479.4
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Light yellow to yellow Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD20036266
SMILES	COC1=CC=C(CCNCC2=CC=C(OCC3=CC=C(Cl)N=C3)C(OC)=C2)C=C1OC.[H]Cl
Target Point	Polo-like Kinase (PLK)
Passage	Cell Cycle
Background	SBE 13 HCl is a potent and selective PLK1 inhibitor.
Biological Activity	SBE13 Hydrochloride 是一种有效的，选择性的 Plk1 抑制剂，IC50 值为 200 pM，对 Plk2 (IC50>66 μM) 或 Plk3 (IC50=875 nM) 的作用较弱。[1-3]
IC50	PLK1:200 pM;PLK3:875nM [1-3]
Data Literature Source	[1]. Keppner S，et al. Identification and validation of a potent type II inhibitor of inactive polo-like kinase 1. ChemMedChem. 2009 Nov;4(11):1806-9. [2]. Keppner S，et al. Fate of primary cells at the G /S boundary after polo-like kinase 1 inhibition by SBE13. Cell Cycle. 2011 Feb 15;10(4):708-20. Epub 2011 Feb 15. [3]. Keppner S，et al. Biological impact of freezing Plk1 in its inactive conformation in cancer cells. Cell Cycle. 2010 Feb 15;9(4):761-73. Epub 2010 Feb 16
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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