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SN-38

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Cat.No：IS2140 Solarbio

CAS：86639-52-3

Molecular Formula：C₂₂H₂₀N₂O₅

Molecular Weight：392.4

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Off-white to yellow Solid

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Product Information

CAS	86639-52-3
Name	SN-38
Molecular Formula	C₂₂H₂₀N₂O₅
Molecular Weight	392.4
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Off-white to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 643-093-9
MDL	MFCD06762720
SMILES	O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=C(CC)C5=CC(O)=CC=C5N=C4C3=C2)=O
Target Point	Topoisomerase
Passage	DNA Damage/DNA Repair
Background	SN-38 can inhibit DNA topoisomerase I, DNA synthesis, and cause frequent DNA single-strand breaks.
Biological Activity	SN-38是拓扑异构酶I抑制剂伊立替康的活性代谢产物。 SN-38抑制DNA合成和RNA 合成的IC50分别为0.077 和 1.3 μM。[1-3]
Data Literature Source	[1]. Wallin A，et al. Anticancer effect of SN-38 on colon cancer cell lines with different metastatic potential. Oncol Rep. 2008 Jun;19(6):1493-8. [2]. Jensen NF，et al. Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a newpair of resistance-associated mutations. J Exp Clin Cancer Res. 2016 Mar 31;35:56. [3]. Stewart CF，et al. Disposition of irinotecan and SN-38 following oral and intravenous irinotecan dosing in mice. Cancer Chemother Pharmacol. 1997;40(3):259-65
Unit	Bottle
Specification	20mg 50mg 100mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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