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VER-155008

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Cat.No：IV0710 Solarbio

CAS：1134156-31-2

Molecular Formula：C₂₅H₂₃Cl₂N₇O₄

Molecular Weight：556.4

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Solid

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Product Information

CAS	1134156-31-2
Name	VER-155008
Molecular Formula	C₂₅H₂₃Cl₂N₇O₄
Molecular Weight	556.4
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD18086892
SMILES	O[C@@H]([C@H]([C@H](N1C(NCC2=CC=C(Cl)C(Cl)=C2)=NC3=C1N=CN=C3N)O4)O)[C@H]4COCC5=CC=C(C#N)C=C5
Target Point	HSP
Passage	Cell Cycle;Metabolic Enzyme&Protease
Background	VER-155008 is a potent Hsp70 family inhibitor.
Biological Activity	VER-155008 is an inhibitor of Hsp70， with IC50s of 0.5 μM， 2.6 μM， and 2.6 μM for Hsp70， Hsc70 and Grp7， respectively， and with a Kd of 0.3 μM for Hsp70.[1-3]
Data Literature Source	[1]. Massey AJ， et al. A novel， small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells. Cancer Chemother Pharmacol. 2010 Aug;66(3):535-45. [2]. Yang X， et al. Heat Shock Cognate 70 Inhibitor， VER-155008， Reduces Memory Deficits and Axonal Degeneration in a Mouse Model of Alzheimers Disease. Front Pharmacol. 2018 Jan 30;9:48. [3]. Kita K， et al. Heat shock protein 70 inhibitors suppress androgen receptor expression in LNCaP95 prostate cancer cells. Cancer Sci. 2017 Sep;108(9):1820-1827.
Unit	Bottle
Specification	5mg 10mg 25mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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