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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cytoskeleton > Vinorelbine TartrateCAS：125317-39-7
Molecular Formula：C45H54N4O8·2C4H6O6
Molecular Weight：1079.11
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 125317-39-7 |
| Name | Vinorelbine Tartrate |
| Molecular Formula | C45H54N4O8·2C4H6O6 |
| Molecular Weight | 1079.11 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 639-264-2 |
| MDL | MFCD03613607 |
| SMILES | CC[C@@]1(C=CCN2CC3)[C@@]2([H])[C@@]3(C(C=C([C@@](C4=C5C(C=CC=C6)=C6N4)(CC(C=C(CC)C7)([H])CN7C5)C(OC)=O)C(OC)=C8)=C8N9C)[C@]9([H])[C@](C(OC)=O)(O)[C@@H]1OC(C)=O.O=C(O)[C@H](O)[C@@H](O)C(O)=O.O=C(O)[C@H](O)[C@@H](O)C(O)=O |
| Target Point | Microtubule/Tubulin |
| Passage | Cytoskeleton |
| Background | Vinorelbine Tartrate is a vinca alkaloid that inhibits mitosis by interacting with tubulin. |
| Biological Activity | Vinorelbine ditartrate 是一种抗有丝分裂剂，能够抑制 Hela 细胞的增殖，IC50值为 1.25 nM。[1-4] |
| Data Literature Source | [1]. Ngan VK， et al. Mechanism of mitotic block and inhibition of cell proliferation by the semisynthetic Vinca alkaloids vinorelbine and its newer derivative vinflunine. Mol Pharmacol. 2001 Jul; 60 (1) :225-32. [2]. Liu XM， et al. Unique induction of p21 (WAF1/CIP1) expression by vinorelbine in androgen-independent prostate cancer cells. Br J Cancer. 2003 Oct 20; 89 (8) :1566-73. [3]. Poirier VJ， et al. Toxicity， dosage， and efficacy of vinorelbine (Navelbine) in dogs with spontaneous neoplasia. J Vet Intern Med. 2004 Jul-Aug; 18 (4) :536-9. [4]. Pierro JA， et al. Phase I clinical trial of vinorelbine in tumor-bearing cats. J Vet Intern Med. 2013 Jul-Aug; 27 (4) :943-8. |
| Unit | Bottle |
| Specification | 5mg 10mg 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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