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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cytoskeleton > Y-33075CAS：199433-58-4
Molecular Formula：C16H16N4O
Molecular Weight：280.32
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 199433-58-4 |
| Name | Y-33075 |
| Molecular Formula | C16H16N4O |
| Molecular Weight | 280.32 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD16038858 |
| SMILES | O=C(NC1=C2C(NC=C2)=NC=C1)C3=CC=C(C=C3)[C@H](N)C |
| Target Point | ROCK |
| Passage | Cytoskeleton; Cell Cycle;TGF-beta/Smad;Stem Cells |
| Background | Y-33075 is a potent ROCK inhibitor. |
| Biological Activity | Y-33075（Y-39983）是一种有效的ROCK抑制剂，IC50为3.6 nM。 Y-33075也比Y-27632更有效地抑制PKC和CaMKII。[1-3] |
| Data Literature Source | [1]. Hideki Tokushige，et al. Effects of Topical Administration of Y-39983，a Selective Rho-Associated Protein Kinase Inhibitor，on Ocular Tissues in Rabbits and Monkeys Invest. Ophthalmol. Vis. Sci. July 2007 vol. 48no. 7 3216-3222 [2]. Tokushige H，et al. Effects of Y-39983，a selective Rho-associated protein kinase inhibitor，on blood flow in optic nerve head in rabbits and axonal regeneration of retinal ganglion cells in rats. Curr Eye Res. 2011 Oct;36(10):964-70. [3]. Watabe H，et al. Effects of Rho-associated protein kinase inhibitors Y-27632 and Y-39983 on isolated rabbit ciliary arteries.Jpn J Ophthalmol. 2011 Jul;55(4):411-7. Epub 2011 Jun 11. |
| Unit | Bottle |
| Specification | 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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