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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cytoskeleton > Y-33075 dihydrochlorideCAS：173897-44-4
Molecular Formula：C16H16N4O·2HCl
Molecular Weight：353.25
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥97%
Appearance：White to off-white Solid
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| CAS | 173897-44-4 |
| Name | Y-33075 dihydrochloride |
| Molecular Formula | C16H16N4O·2HCl |
| Molecular Weight | 353.25 |
| Solubility | Soluble in Water/DMSO |
| Purity | ≥97% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00945328 |
| SMILES | O=C(C1=CC=C([C@@H](C)N)C=C1)NC2=C3C(NC=C3)=NC=C2.[H]Cl.[H]Cl |
| Target Point | ROCK |
| Passage | Cytoskeleton; Cell Cycle;TGF-beta/Smad;Stem Cells |
| Background | It is a selective ROCK inhibitor. |
| Biological Activity | Y-33075 dihydrochloride is a selective ROCK inhibitor with an IC50 of 3.6 nM.[1-3] |
| Data Literature Source | [1]. Hideki Tokushige， et al. Effects of Topical Administration of Y-39983， a Selective Rho-Associated Protein Kinase Inhibitor， on Ocular Tissues in Rabbits and Monkeys Invest. Ophthalmol. Vis. Sci. July 2007 vol. 48no. 7 3216-3222 [2]. Tokushige H， et al. Effects of Y-39983， a selective Rho-associated protein kinase inhibitor， on blood flow in optic nerve head in rabbits and axonal regeneration of retinal ganglion cells in rats. Curr Eye Res. 2011 Oct;36(10):964-70. [3]. Watabe H， et al. Effects of Rho-associated protein kinase inhibitors Y-27632 and Y-39983 on isolated rabbit ciliary arteries.Jpn J Ophthalmol. 2011 Jul;55(4):411-7. Epub 2011 Jun 11. |
| Unit | Bottle |
| Specification | 2mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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