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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > AG-14361CAS：328543-09-5
Molecular Formula：C19H20N4O
Molecular Weight：320.39
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 328543-09-5 |
| Name | AG-14361 |
| Molecular Formula | C19H20N4O |
| Molecular Weight | 320.39 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00040495 |
| SMILES | O=C1NCCN2C3=C1C=CC=C3N=C2C4=CC=C(C=C4)CN(C)C |
| Target Point | PARP |
| Passage | Cell Cycle;DNA Damage/DNA Repair; Epigenetics |
| Background | AG14361 is a potent PARP1 inhibitor. |
| Biological Activity | AG14361 是一种有效的 PARP-1 抑制剂，Ki 值 < 5 nM，在通透的 SW620 细胞和完整的 SW620 细胞中，抑制 PARP-1 的活性，IC50 值分别为 29 nM 和 14 nM。[1-3] |
| Data Literature Source | [1]. Calabrese CR， et al. Anticancer chemosensitization and radiosensitization by the novel poly (ADP-ribose) polymerase-1 inhibitor AG14361. J Natl Cancer Inst. 2004 Jan 7; 96 (1) :56-67. [2]. Vazquez-Ortiz G， et al. Drug repurposing screen identifies lestaurtinib amplifies the ability of the poly (ADP-ribose) polymerase 1 inhibitor AG14361 to kill breast cancer associated gene-1 mutant and wild type breast cancer cells. Breast Cancer Res. 2014 Jun 24; 16 (3) :R67. [3]. Smith LM， et al. The novel poly (ADP-Ribose) polymerase inhibitor， AG14361， sensitizes cells to topoisomerase I poisons by increasing the persistence of DNA strand breaks. Clin Cancer Res. 2005 Dec 1; 11 (23) :8449-57. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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