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T-0070907

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Cat.No：IT1670 Solarbio

CAS：313516-66-4

Molecular Formula：C₁₂H₈ClN₃O₃

Molecular Weight：277.66

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to yellow Solid

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Product Information

CAS	313516-66-4
Name	T-0070907
Molecular Formula	C₁₂H₈ClN₃O₃
Molecular Weight	277.66
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to yellow Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD00121849
SMILES	ClC1=C(C=C(C=C1)[N+]([O-])=O)C(NC2=CC=NC=C2)=O
Target Point	PPAR
Passage	Cell Cycle;DNA Damage/DNA Repair;Metabolic Enzyme&Protease
Background	T0070907 is a potent and selective PPARγ inhibitor.
Biological Activity	T0070907是有效的 PPARγ 拮抗剂，Ki值为1 nM。T0070907（10μM）具有脂肪细胞特异性和PPARγ非依赖性细胞毒性。[1-4]
Data Literature Source	[1]. An Z，et al. T0070907 inhibits repair of radiation-induced DNA damage by targeting RAD51. Toxicol In Vitro. 2016 Dec;37:1-8 [2]. An Z，et al. T0070907，a PPAR γ inhibitor，induced G2/M arrest enhances the effect of radiation in human cervical cancer cells through mitotic catastrophe. Reprod Sci. 2014 Nov;21(11):1352-61. [3]. Kawahara A，et al. Peroxisome proliferator-activated receptor γ (PPARγ)-independent specific cytotoxicity against immature adipocytes induced by PPARγ antagonist T0070907. Biol Pharm Bull. 2013;36(9):1428-34 [4]. Lee G，et al. T0070907，a selective ligand for peroxisome proliferator-activated receptor gamma，functions as an antagonist of biochemical and cellular activities. J Biol Chem. 2002 May 31;277(22):19649-57. Epub 2002 Mar 4
Unit	Bottle
Specification	5mg 10mM*1mL in DMSO 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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