Your Position: Home > Small Molecule Compounds > Inhibitors & Antagonists & Agonists > DNA Damage & DNA Repai > Teniposide

Teniposide

Manual Download

Cat.No：IT1680 Solarbio

CAS：29767-20-2

Molecular Formula：C₃₂H₃₂O₁₃S

Molecular Weight：656.65

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

Qty：

Size：

Add to cart

Product Information Experimental Images Related Products Related Paper Technical Q&A

Product Information

CAS	29767-20-2
Name	Teniposide
Molecular Formula	C₃₂H₃₂O₁₃S
Molecular Weight	656.65
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 249-831-2
MDL	MFCD00866516
SMILES	O=C1OC[C@]2([H])[C@H](O[C@H]3[C@@H]([C@H]([C@@H]([C@@H](CO4)O3)O[C@@H]4C5=CC=CS5)O)O)C6=C(C=C7OCOC7=C6)[C@@H](C8=CC(OC)=C(O)C(OC)=C8)[C@]21[H]
Target Point	Topoisomerase
Passage	DNA Damage/DNA Repair
Background	It acts by forming a ternary complex with topoisomerase II and DNA, acting in the late S phase or early G phase of the cell cycle. Related research for childhood acute lymphoblastic leukemia (ALL).
Biological Activity	Teniposide 是一种足叶草毒素衍生物，是拓扑异构酶 II (topoisomerase II) 的抑制剂，同时为一种化疗剂。[1-3]
Data Literature Source	[1]. Attia SM，et al. Molecular cytogenetic evaluation of the aneugenic effects of teniposide in somatic and germinal cells of male mice. Mutagenesis. 2012 Jan;27(1):31-9. [2]. Li J，et al. Topoisomerase II trapping agent teniposide induces apoptosis and G2/M or S phase arrest of oral squamous cell carcinoma. World J Surg Oncol. 2006 Jul 6;4:41. [3]. Sun YC，et al. MiR-181b sensitizes glioma cells to teniposide by targeting MDM2. BMC Cancer. 2014 Aug 25;14:611
Unit	Bottle
Specification	25mg 10mM*1mL in DMSO 50mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

Note：

1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.

2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.

3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.