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VE-821

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Cat.No：IV0680 Solarbio

CAS：1232410-49-9

Molecular Formula：C₁₈H₁₆N₄O₃S

Molecular Weight：368.41

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Light green to green Solid

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Product Information

CAS	1232410-49-9
Name	VE-821
Molecular Formula	C₁₈H₁₆N₄O₃S
Molecular Weight	368.41
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Light green to green Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD19443686
SMILES	O=C(NC1=CC=CC=C1)C2=NC(C3=CC=C(C=C3)S(=O)(C)=O)=CN=C2N
Target Point	ATM/ATR
Passage	DNA Damage/DNA Repair; PI3K/Akt/mTOR
Background	VE-821 is a potent, selective, ATP-competitive ATR inhibitor.
Biological Activity	VE-821 是一种有效的 ATP 竞争性的 ATR 抑制剂，Ki/IC50 为 13 nM/26 nM。 VE-821也抑制ATM和DNA-PK，IC50分别>8μM和4.4μM。[1-4]
Data Literature Source	[1]. Reaper PM，et al. Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR. Nat Chem Biol. 2011 Apr 13;7(7):428-30. [2]. Charrier JD，et al. Discovery of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents. J Med Chem. 2011 Apr 14;54(7):2320-30. [3]. Prevo R，et al. The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy. Cancer Biol Ther. 2012 Sep;13(11):1072-81. [4]. Muralidharan SV，et al. BET bromodomain inhibitors synergize with ATR inhibitors to induce DNA damage，apoptosis，senescence-associated secretory pathway and ER stress in Myc-induced lymphoma cells. Oncogene. 2016 Sep 8;35(36):4689-97
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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