{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > BMN-673CAS：1207456-01-6
Molecular Formula：C19H14F2N6O
Molecular Weight：380.35
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 1207456-01-6 |
| Name | BMN-673 |
| Molecular Formula | C19H14F2N6O |
| Molecular Weight | 380.35 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD22666357 |
| SMILES | O=C1NN=C2C3=C1C=C(F)C=C3N[C@H](C4=CC=C(F)C=C4)[C@H]2C5=NC=NN5C |
| Target Point | PARP |
| Passage | Cell Cycle;DNA Damage/DNA Repair; Epigenetics |
| Background | BMN-673 is a novel PARP inhibitor. |
| Biological Activity | Talazoparib (BMN-673) 是高效的 PARP1/2 抑制剂，Ki 值分别为 1.2 nM 和 0.87 nM。Talazoparib具有抗肿瘤活性[1-2] |
| Data Literature Source | [1]. Wang B，et al. Discovery and Characterization of (8S，9R)-5-Fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1，2，4-triazol-5-yl)-2，7，8，9-tetrahydro-3H-pyrido[4，3，2-de]phthalazin-3-one (BMN 673，Talazoparib)，a Novel，Highly Potent，and Orally Efficacious Poly(ADP- [2]. Shen Y，et al. BMN 673，a novel and highly potent PARP1/2 inhibitor for the treatment of human cancers with DNA repair deficiency.Clin Cancer Res. 2013 Sep 15;19(18):5003-15. |
| Unit | Bottle |
| Specification | 2mg 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
