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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > AZD-2461CAS：1174043-16-3
Molecular Formula：C22H22FN3O3
Molecular Weight：395.43
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1174043-16-3 |
| Name | AZD-2461 |
| Molecular Formula | C22H22FN3O3 |
| Molecular Weight | 395.43 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD24386811 |
| SMILES | O=C1NN=C(CC2=CC=C(F)C(C(N3CCC(OC)CC3)=O)=C2)C4=C1C=CC=C4 |
| Target Point | PARP |
| Passage | Cell Cycle;DNA Damage/DNA Repair; Epigenetics |
| Background | AZD2461 is a novel PARP inhibitor. |
| Biological Activity | AZD-2461 是一种有效的 PARP 抑制剂，可抑制 PARP1，PARP2 和 PARP3 的活性，IC50 值分别为 5 nM，2 nM 和 200 nM。 |
| IC50 | PARP1:5nM;PARP2:2nM;PARP3:200nM [1-3] |
| Data Literature Source | [1]. Oplustil O'Connor L，et al. The PARP Inhibitor AZD2461 Provides Insights into the Role of PARP3 Inhibition for Both Synthetic Lethality and Tolerability with Chemotherapy in Preclinical Models. Cancer Res. 2016 Oct 15;76(20):6084-6094. Epub 2016 Aug 22. [2]. W sierska-G dek J，et al. Differential Potential of Pharmacological PARP Inhibitors for Inhibiting Cell Proliferation and Inducing Apoptosis in Human Breast Cancer Cells. J Cell Biochem. 2015 Dec;116(12):2824-39. [3]. Jaspers JE，et al. Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors. Cancer Discov. 2013 Jan;3(1):68-81 |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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