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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > CX-5461CAS：1138549-36-6
Molecular Formula：C27H27N7O2S
Molecular Weight：513.61
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 1138549-36-6 |
| Name | CX-5461 |
| Molecular Formula | C27H27N7O2S |
| Molecular Weight | 513.61 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD03840500 |
| SMILES | CC1=NC=C(CNC(C2=C3N(C4=NC(N5CCN(CCC5)C)=CC=C4C2=O)C6=C(S3)C=CC=C6)=O)N=C1 |
| Target Point | DNA/RNA Synthesis |
| Passage | Cell Cycle;DNA Damage/DNA Repair |
| Background | CX-5461 is an rRNA synthesis inhibitor that selectively inhibits Pol I-driven rRNA transcription. |
| Biological Activity | CX-5461是一种有效的rRNA合成抑制剂。 它在HCT-116，A375和MIA PaCa-2细胞中抑制RNA聚合酶I驱动的rRNA转录，IC50为142，113和54 nM[1-2]。 |
| Data Literature Source | [1]. Drygin D et al. Targeting RNA polymerase I with an oral small molecule CX-5461 inhibits ribosomal RNA synthesis and solid tumor growth. Cancer Res. 2011 Feb 15;71(4):1418-30. [2]. Bywater MJ，et al. Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53.Cancer Cell. 2012 Jul 10;22(1):51-65 |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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