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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > DNA Damage & DNA Repai > CP-466722CAS：1080622-86-1
Molecular Formula：C17H15N7O2
Molecular Weight：349.35
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1080622-86-1 |
| Name | CP-466722 |
| Molecular Formula | C17H15N7O2 |
| Molecular Weight | 349.35 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 808-414-0 |
| MDL | MFCD17392566 |
| SMILES | NC1=NC(C2=NC=CC=C2)=NN1C3=C4C=C(OC)C(OC)=CC4=NC=N3 |
| Target Point | ATM/ATR |
| Passage | DNA Damage/DNA Repair; PI3K/Akt/mTOR |
| Background | CP-466722 is a potent, reversible ATM inhibitor. |
| Biological Activity | CP-466722 是一种可逆的 ATM 抑制剂，IC50 值为 4.1 μM，但对 PI3K，PIKK 家族蛋白没有作用[1-3]。 |
| IC50 | ATM:4.1μM [1-3] |
| Data Literature Source | [1]. Rainey MD，et al. Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation. Cancer Res. 2008 Sep 15;68(18):7466-74. [2]. Guo K，et al. Development of a cell-based，high-throughput screening assay for ATM kinase inhibitors. J Biomol Screen. 2014 Apr;19(4):538-46. [3]. W sierska-G dek J，et al. Interactions Between Ataxia Telangiectasia Mutated Kinase Inhibition，Poly(ADP-ribose) Polymerase-1 Inhibition and BRCA1 Status in Breast Cancer Cells. J Cancer Prev. 2014 Jun;19(2):125-36. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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